Systemic Complement Activation in Age-Related Macular Degeneration

Scholl HPN, Issa PC, Walier M, Janzer S, Pollok-Kopp B, et al. (2008) Systemic Complement Activation in Age-Related Macular Degeneration. PLoS ONE 3(7): e2593 doi:10.1371/journal.pone.0002593 This study is the first to show systemic complement activation in AMD patients. This suggests that AMD is a systemic disease with local disease manifestation at the ageing macula. Furthermore, the data provide evidence for an association of systemic activation of the alternative complement pathway with genetic variants of CFH that were previously linked to AMD susceptibility. Read Article