The practice of targeting influenza vaccine to older people has only poor-quality supporting evidence that fails to show a clear benefit or harm, authors of a systematic review concluded.
The only randomized, controlled trial of acceptable quality "seemed" to show a beneficial effect of vaccination against influenza symptoms but lacked statistical power to examine the effect on complications.
"The available evidence is of poor quality and provides no guidance regarding the safety, efficacy, or effectiveness of influenza vaccines for people ages 65 years or older," Tom Jefferson, MD, of the Cochrane Collaboration in Rome, and colleagues wrote in an article published in The Cochrane Library.
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