Male infertility may be an early and identifiable risk factor for the later development of aggressive prostate cancer, a large study found.
On multivariate analysis, men with male factor infertility were 2.6 times more likely to develop high-grade prostate cancer than those without fertility problems (HR 2.6, 95% CI 1.4 to 4.8, P=0.003), according to Thomas J. Walsh, MD, of the University of Washington in Seattle, and colleagues.
This finding emerged from an analysis of data from a cohort of 22,562 men in California who sought evaluation for infertility between 1967 and 1998, the investigators reported online in Cancer.
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