Chemotherapy-related cognitive changes had significant associations with older age and lower baseline cognitive reserve, data from a case-control study of breast cancer patients showed.
Older patients with lower cognitive reserve who were treated with chemotherapy scored significantly lower on tests of processing speed than women treated only with tamoxifen (P=0.003) and a healthy control group (P<0.001),>Journal of Clinical Oncology.
Chemotherapy also appeared to have a temporary adverse effect on verbal ability, which differed significantly from the tamoxifen-only and control groups at one month (P=0.01). Verbal ability improved, however, during two subsequent follow-up evaluations of patients who received chemotherapy.
The findings suggest that pretreatment factors, as well as various aspects of breast cancer and its therapy, have an impact on cognitive functioning, the researchers wrote.
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