Saturday, February 12, 2011

Early BP Lowering No Help in Acute Stroke

By Crystal Phend, Senior Staff Writer, MedPage Today

Lowering blood pressure early during acute stroke did nothing to improve outcomes and may actually impair patients' ability to live independently later on, researchers affirmed in a randomized trial.

Candesartan (Atacand) started within 30 hours of stroke onset and given over seven days did not affect the combined six-month rate of death from vascular causes, myocardial infarction, or stroke compared with placebo (11.7% versus 11.3%, adjusted hazard ratio 1.09, P=0.52), Eivind Berge, MD, of Oslo University Hospital UllevÄl, and colleagues found.

Functional disability was 17% more common with the drug (P=0.048), the group reported here at the American Stroke Association's International Stroke Conference and simultaneously online in The Lancet.
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