Wednesday, February 16, 2011

Study Suggests Lower PSA Cutoff for Biopsy

By Charles Bankhead, Staff Writer, MedPage Today

An initial PSA value <3 ng/mL predicted a low risk of prostate cancer and a remote likelihood that a man would die of the disease, results of a large screening study showed.

Fewer than 6% of men developed prostate cancer over an 11-year period following a first-time screening PSA value lower than 3 ng/mL. Subsequently, 23 men died of the disease, resulting in a mortality of 0.15%, Dutch investigators reported in a study that will be presented here at the Genitourinary Cancers Symposium later this week.

The median time to diagnosis of prostate cancer in men with the lowest initial PSA values exceeded eight years, said Monique Roobol, MD, of Erasmus University Medical Center in Rotterdam.

The low cancer risk and prolonged interval to diagnosis have potentially major implications for use of PSA to screen for prostate cancer.

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