There is no "safe" duration for NSAID use in patients with a history of myocardial infarction, according to an analysis of data from more than 83,000 patients -- use of NSAIDs after MI increased the relative risk of death or second MI by as much as 45%.
Moreover, the common NSAID diclofenac (Voltaren, Cataflam) was associated with a 3.52 HR for death during the first week of use, according to Anne-Marie Schjerning Olsen, MB, of Copenhagen University Hospital in Gentofte, Denmark, and colleagues.
That's a higher risk of death at the initiation of treatment than was seen with rofecoxib (Vioxx), which was withdrawn from the market in 2004, they wrote online in Circulation, Journal of the American Heart Association.
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