Planning Grants For Translational Research For The Prevention And Control Of Diabetes And Obesity

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) seeks to develop cost effective and sustainable interventions, that can be adopted in real world settings, for the prevention and control of diabetes and obesity. Research should be based on interventions already proven efficacious in clinical trials to prevent and reverse obesity and type 2 diabetes, to improve care of type 1 and type 2 diabetes and to prevent or delay its complications. The interventions proposed under this solicitation should have the potential to be widely disseminated to clinical practice, individuals and communities at risk.

This FOA invites research applications for planning grants or pilot studies for translational/dissemination research leading to full scale research in diabetes prevention and control as described in the program announcement, PA-02-153-Relevant topics include
1) methods to improve health care delivery to patients with or at risk of diabetes,
2) to enhance diabetes self management,
3) methods to develop strategies to promote healthy lifestyles to reduce the risk of diabetes,
4) methods to promote lifestyle change that will prevent or reverse overweight and obesity, and
5) new cost effective ways to identify people with pre-diabetes and undiagnosed diabetes.

Important considerations are cost effectiveness and sustainability of the intervention(s) proposed and the ability of interventions to be widely disseminated in settings such as representative health care systems, schools, worksites, or other community settings.

Proposals should test cost effective and sustainable strategies that go beyond research settings to achieve
1) control of glycemia and other risk factors for diabetic complications, including hypertension and dyslipidemia
2) alteration in life style to prevent or reverse overweight, obesity, pre-diabetes, or type 2 diabetes in at-risk populations.

Studies submitted to this program should focus on developing preliminary data demonstrating that the proposed approach is feasible and leads to reduced body weight and or improved glycemia. The interventions proposed must have the clear potential to be applied beyond research settings and to be widely implemented in existing settings in the U.S.

Proposals focused on minorities and other high risk populations disproportionately affected by diabetes and obesity are encouraged.