The gains bisphosphonate use brings in the structural integrity of the femur decay over time in postmenopausal women with osteoporosis, researchers found.
In women who took oral bisphosphonates for four to five years, buckling ratio, a measure of structural integrity, improved significantly in the proximal femur from baseline, according to Anthony Ding, a medical student at Columbia University College of Physicians and Surgeons in New York City.
However, those improvements started to erode and creep back toward pretreatment levels when bisphosphonate use lasted more than five years, he reported at the American Academy of Orthopaedic Surgeons meeting.
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